Applications are invited for a 3-year PhD fellowship on understanding the molecular interactions that produce post translational modifications of secreted proteins and applying that knowledge towards production of pharmaceutical biologics. The project will be carried out at the Novo Nordisk Foundation Center for Biosustainability, Technical University of Denmark (DTU) in the CHO cell line engineering and development group under supervision of Dr. Lasse Ebdrup Pedersen.
The mammalian bio-pharmaceutical industry produces therapeutic proteins to treat numerous diseases such as cancer, anemia and haemophilia. The most used mammalian cell factory is the Chinese hamster ovary (CHO) cell. Our group is a world leading CHO research group and we seek to improve our understanding of basic cell biology in the area of protein production and to apply that knowledge to predictably produce high quantity and high quality therapeutic proteins.
Responsibilities and tasks
The candidate will do research in the area of post-translational modifications during protein production. The candidate will employ advanced molecular biology tools and the latest -omic technologies, including genomics, proteomics and data analysis.
Your responsibilities will include:
- Wet lab work on molecular biology, mammalian cell biology and high-throughput screening.
- Computational work on -omic data analysis
- Dissemination of results through scientific publications, patents and conference presentations.
- Supervision of MSc or BSc students.
The PhD study also comprises courses equivalent to 30 ECTS credits and an international secondment of 3-6 months duration.
Candidates should have a master’s degree in engineering or a similar degree with an academic level equivalent to the master’s degree in engineering. A degree in Molecular biology, Biotechnology or similar is preferred.
The candidate should possess most of the following:
- Ability to work independently, to plan and carry out complicated research tasks, and also to be a part of the large research team;
- Team spirit and excellent collaboration skills
- Proficiency with sterile mammalian cell work and molecular biology techniques
- Computer proficiency. Ideally proficient in python.
- Strong analytical skills and excellent judgment ability
- Excellent communication skills, fluent written and oral English
- Well-organized, efficient, result-oriented, have excellent record keeping abilities.
Approval and Enrolment
The scholarship for the PhD degree is subject to academic approval, and the candidate will be enrolled in one of the general degree programmes at DTU. For information about our enrolment requirements and the general planning of the PhD study programme, please see the DTU PhD Guide .
The assessment of the applicants will be made by Lasse Ebdrup Pedersen.
DTU is a leading technical university globally recognized for the excellence of its research, education, innovation and scientific advice. We offer a rewarding and challenging job in an international environment. We strive for academic excellence in an environment characterized by collegial respect and academic freedom tempered by responsibility.
Salary and appointment terms
The appointment will be based on the collective agreement with the Danish Confederation of Professional Associations. The allowance will be agreed upon with the relevant union. The period of employment is 3 years.
You can read more about career paths at DTU here .
Workplace will be at DTU Lyngby Campus.
Further information may be obtained from Dr. Lasse Ebdrup Pedersen, [email protected] .
You can read more about DTU Biosustain at www.biosustain.dtu.dk .
Please submit your online application no later than 2 November 2018 (local time). Applications must be submitted as one PDF file containing all materials to be given consideration. To apply, please open the link “Apply online”, fill out the online application form, and attach all your materials in English in one PDF file. The file must include:
- A letter motivating the application (cover letter)
- Curriculum vitae
- Grade transcripts and BSc/MSc diploma
- Excel sheet with translation of grades to the Danish grading system (see guidelines and Excel spreadsheet here )
Candidates may apply prior to obtaining their master’s degree but cannot begin before having received it.
Applications and enclosures received after the deadline will not be considered.
All interested candidates irrespective of age, gender, race, disability, religion or ethnic background are encouraged to apply.
The Novo Nordisk Foundation Center for Biosustainability is an international research center at the Technical University of Denmark primarily funded by a grant from the Novo Nordisk Foundation. The center conducts research in engineering of cell factories and in silico systems biology, with the purpose of developing new processes and technologies that can support a more sustainable bio-based production of valuable chemicals in the future. The center brings together some of the world’s leading researchers in the field and possesses the advanced equipment and facilities required for achieving its ambitious research goals. Impact on society by innovation has a high priority and the center collaborates worldwide with biotech companies and chemical industries to facilitate the dissemination and exploitation of its results.
DTU is a technical university providing internationally leading research, education, innovation and scientific advice. Our staff of 6,000 advance science and technology to create innovative solutions that meet the demands of society, and our 11,200 students are being educated to address the technological challenges of the future. DTU is an independent academic university collaborating globally with business, industry, government and public agencies.
PhD fellowship in prevention of post-weaning diarrhoea in pigs at Department of Veterinary and Animal Sciences
We are offering a PhD scholarship inprevention of post-weaning diarrhoea in pigs commencing 31 December 2018.
Our group and research
In our section with
approximately 50 employees we are working with production, nutrition and health
aspects in farmed animals. The pig health research group with approximately 10
employees has a strong focus on tools for antibiotic reduction in pig herds.
The aim of the project is to test E. coli specific bacteriophages used for
prevention of post-weaning diarrhoea in piglets.
Principal supervisor is Professor
Jens Peter Nielsen, Department of
Veterinary and Animal Sciences; e-mail [email protected], phone +45 2125 5926.
Your key tasks as a PhD student are:
- Carry through an
independent research project under supervision.
- Complete PhD courses or other equivalent education corresponding
to approx. 30 ECTS points.
- Participate in active research environments including a stay at
another research team.
- Obtain experience with teaching or other types of dissemination related
to your PhD project.
- Teach and disseminate your research.
- Write a PhD thesis on the grounds of your project.
Key criteria for the assessment of candidates
Applicants must have qualifications corresponding to a master’s degree related
to the subject area of the project e.g. veterinary medicine.
grade point average achieved
qualifications relevant to the PhD programme
- License to carry
out animal experiments in Denmark
- Previous publications
- Relevant work experience
- Other professional activities
- Curious mind-set
with a strong interest in pig health
- Language skills.
The place of employment is at Department of Veterinary and Animal Sciences,
Frederiksberg, University of
Copenhagen. We offer creative and stimulating working conditions in dynamic and
international research environment.
Terms of employment and employment
The employment as PhD fellow is a full
time and for 3 years. Starting date is December 31, 2018, or after agreement.
The appointment as a PhD fellow is for 3
years. It is conditioned upon the candidate’s successful enrolment in the PhD
school at the Faculty of Health and Medical Sciences, University of Copenhagen.
This requires submission and acceptance of an application for the specific
project formulated by the applicant.
The PhD study must be
completed in accordance with The Ministerial Order on the PhD programme (2013)
and the University’s rules on achieving the degree. Salary, pension and terms
of employment are in accordance with the agreement between the Ministry of
Finance and The Danish Confederation of Professional Associations on Academics
in the State. Depending on seniority, the monthly salary begins around 26,755
DKK /approx. 3,567 EUR (April 2018-level) plus pension.
For specific information about the PhD
scholarship, please contact the principal supervisor.
Your application must be submitted
electronically by clicking ‘Apply now’
below. The application must include the following documents in PDF format:
relevant for the position.
completed, a certified/signed copy of a recent transcript of records or a
written statement from the institution or supervisor will do.
Application deadline: 15 November 2018,
23.59 pm CET.
We reserve the right not to consider material received after the
deadline, and not to consider applications that do not live up to the
The further process
After the expiry of the deadline for
applications, the authorized recruitment manager selects applicants for
assessment on the advice of the hiring committee. All applicants are then
immediately notified whether their application has been passed for assessment by
an unbiased assessor.
The assessor makes a non-prioritized assessment of the academic qualifications and experience with
respect to the above-mentioned area of research, techniques, skills and other
requirements listed in the advertisement.
Once the assessment work has been completed each applicant has the
opportunity to comment on the part of the assessment that relates to the
The applicant will be assessed according to the Ministerial Order no.
242 of 13 March 2012 on the Appointment of Academic Staff at Universities.
expected to be held in week 50.
The University of Copenhagen wish to reflect the diversity of society
and welcome applications from all qualified candidates regardless of personal
Part of the International Alliance of Research Universities (IARU), and among Europe’s top-ranking universities, the University of Copenhagen promotes research and teaching of the highest international standard. Rich in tradition and modern in outlook, the University gives students and staff the opportunity to cultivate their talent in an ambitious and informal environment. An effective organisation – with good working conditions and a collaborative work culture – creates the ideal framework for a successful academic career.
Part time position as senior researcher 979414
Applications are invited for a position as a senior researcher at Department of Biomedicine, Faculty of Health, Aarhus University with start on 1 August 2018 or as soon as possible thereafter. The position is part time (18 hours/week).
The position is dedicated to research in functional and structural studies of membranes and their interaction with membrane proteins. In particular ion-channels and membrane transporters in relation to the identification and exploration of appropriate compounds that interact with these targets and thereby can lead to the development of drugs useful in the treatment for various diseases and medical conditions.
The successful candidate will be expected to carry on research related to the function of ion-channels and artificial build ion-channels with focus on biochemical characterization, structural studies and drug development.
The candidate is expected to have a thorough knowledge and experience in the field of membrane proteins, including their expression, biochemical characterization and structure determination. The candidate will furthermore be expected to master structure determination of complexes of targets and drug candidates, structure-based drug design and docking procedures for development of new drug candidates.
The candidate will in addition to the mentioned researched be expected to acts as Research Business Manager for the department. This entails:
take the initiative and support cooperation with business and industry, other units at Aarhus University or other parties
help to ensure that relevant information finds the right recipient, regardless of whether the recipient is located at the ambassador’s own department or unit or elsewhere in the university or its surroundings
ensure the gathering of experience and internal coordination at Aarhus University
For further information please contact Head of Department of Biomedicine, Thomas G. Jensen by email [email protected] (please note that applications cannot be sent to this e-mail address – see section on application below).
Appointment as a senior researcher requires research and teaching qualifications at such level as can be attained following a satisfactory period of appointment as a researcher, but which could also be achieved otherwise. It is assumed that applicants have received supervision and training in university education and have received a positive written assessment of their teaching qualifications.
Formalities and references
Applications must be accompanied by a CV, diploma, a list of publications, a research plan as well as a teaching portfolio. A maximum of ten of the publications of greatest relevance to the job must be submitted. If you have an assessment within the same job title (completed after March 1, 2016 at AU, Health), then this can be attached to the application.
Further information on the application and supplementary materials may be found in the faculty’s Guidelines for applicants and Aarhus University’s Guidelines on the use of teaching portfolios .
The assessment committee may decide to include non-submitted material in its assessment. In such cases, the applicant will be informed and obliged to submit material, unless the application is withdrawn.
Applications submitted through channels other than the online application form below or applications which are not received by the application deadline will not be considered.
All interested candidates are encouraged to apply, regardless of their personal background.
All applications must be made online and received by:
Please apply online here
Aarhus University is an academically diverse and research-intensive university with
a strong commitment to high-quality research and education and the development of society
nationally and globally. The university offers an inspiring research and teaching environment
to its 40,000 students and 8,000 employees, and has an annual budget of EUR 860 million
Learn more at www.au.dk/en .
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