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Netherlands Scholarships

PhD position, department of Immunopathology

We seek a PhD student to investigate the role of DAMPs in the pathogenesis of platelet refractoriness, The project forms part of a research program (3 PhD students) on the immunological aspects of platelet transfusion. The research will take place within the Department of Immunopathology at Sanquin as well as at the Academic Medical Center (AMC). For the purpose of the project we will closely collaborate with Dr. Pieter van der Meer from the Department of Clinical Transfusion Research.

Platelet refractoriness is associated with morbidity and mortality in patients receiving myeloablative chemotherapy. Preformed, or newly formed anti-HLA or anti-human platelet antibodies that arise after repetitive transfusion of 5-donor-platelet concentrates, induce refractoriness in a significant percentage of these patients. However, only in part of these patients the transfusion of HLA- and/or HPA matched platelet concentrates results in satisfactory platelet recovery, indicating that other factors than anti-platelet antibodies must contribute to refractoriness. Systemic inflammation forms an inherent feature of myeloablative chemotherapy, since widespread cell damage induced by chemotherapy occurs. This is accompanied by the release of DAMPs, such as cell-free DNA, histones, and DNA-binding proteins. Neutropenic fever further complicates the pancytopenic period after myeloablative chemotherapy. In addition, DAMPs may potentially also arise in the platelet product during the manufacturing process or during storage, and contribute to systemic inflammation in the recipient of the platelet product, and hence refractoriness. We have recently described that Factor VII activating protease (FSAP) induces the release of nuclear DAMPs (e.g. nucleosomes) and subsequently neutralizes the cytotoxic effects of these DAMPs, i.e. histones through their degradation. The aim of the current project is to investigate the role of systemic inflammation and DAMPs release in the pathogenesis of platelet refractoriness, and to study the potential therapeutic effects of FSAP to neutralize these DAMPs. The present project will make use of a translational approach, combining in vivo studies in mice and functional studies with human platelet concentrates in vitro.

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Where you will work:

The research group of Prof. Sacha Zeerleder and Dr Brenda Luken, in the department of Immunopathology, studies the inflammation induced by damage-associated molecular pattern (DAMPs), e.g. cell-free DNA, histones, and heme. Our research focuses on the specific consequences of the various DAMPs in the pathogenesis of inflammation, the mechanisms of DAMPs release, and how circulating DAMPs may be neutralized to overcome their detrimental effects.

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Masters Scholarships

Stardust Culminating Experience Scholarship

The Stardust Center for Affordable Homes and the Family is offering a limited number of scholarships to support Master of Sustainability Solutions (MSUS) students who have proposed culminating experience projects designed to address and advance the need for affordable housing, recognizing that healthy sustainable communities provide a means for families to obtain, remain in and manage their homes.

Culminating experience projects may use the tools of research, community engagement, education, and public forums to raise awareness and build capacity to address the needs for quality affordable homes.

Culminating experience projects may use the tools of research, community engagement, education, and public forums to raise awareness and build capacity to address the needs for quality affordable homes.

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Netherlands Scholarships

Work Study Student


Position Details

Position Details

Requisition NumberSTU003119
Classification TitleWork Study Student
Working TitleStudent Accessibility Resource Center – Student Assistant (Spring 2018)
Department3900800302-CWSP-On-campus
LocationMain Campus – Statesboro
Position Summary

Performs various administrative duties including providing support to our Test Proctoring Center and volunteer programs (note taking/mentoring); greeting visitors and directing them to the appropriate area; checking in students and others who have scheduled appointments; answering incoming phone calls and routing them to the correct staff member; taking messages as needed; assisting front office staff members with duties such as filing, copying, and faxing documents.

Shift Specifics: 9 hours per week; flexible with class schedule.

Student employees cannot work more than 1300 hours in a 12-consecutive month period.

Georgia Southern University is a tobacco and smoke-free campus. All faculty, staff, and students must adhere to the established University System of Georgia policy.

Minimum Education Required

Must possess a Federal Work-Study Award.

Could a level of job-related experience higher than the minimum required for the position substitute for the minimum level of education?No
Minimum Experience Required

None

Could a level of education higher than the minimum required for the position substitute for the minimum level of job-related experience?No
Knowledge, Skills & Abilities

Effective communication (verbal and written), organization and human relations skills; ability to work well in a diverse environment; proficiency with computer and Microsoft Office Applications software including word processing, spreadsheets, and databases; successful completion of the background investigation process.

Preferred Experience
Preferred Education
Salary Range$7.25 per hour
Job Open Date04/06/2018
Job Close Date04/27/2018
Position StatusPart-Time
Special Instructions for Applicants
Quicklink for Postinghttp://employment.georgiasouthern.edu/postings/45548
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Netherlands Scholarships

Work Study Student


Position Details

Position Details

Requisition NumberSTU003122
Classification TitleWork Study Student
Working TitlePsychology – Student Assistant (Summer 2018)
Department3900800302-CWSP-On-campus
LocationMain Campus – Statesboro
Position Summary

Provides customer service, runs campus errands, assists administrative staff, facilities monitoring, performs general administrative tasks, answers and transfers telephone calls, files documents and paperwork.

Shift Specifics: 10 – 12 hours per week; flexible with class schedule.

Student employees cannot work more than 1300 hours in a 12-consecutive month period.

Georgia Southern University is a tobacco and smoke-free campus. All faculty, staff, and students must adhere to the established University System of Georgia policy.

Minimum Education Required

Must possess a Federal Work-Study Award.

Could a level of job-related experience higher than the minimum required for the position substitute for the minimum level of education?No
Minimum Experience Required

None

Could a level of education higher than the minimum required for the position substitute for the minimum level of job-related experience?No
Knowledge, Skills & Abilities

Effective communication (verbal and written), organization and human relations skills; ability to work well in a diverse environment; proficiency with computer and Microsoft Office Applications software including word processing, spreadsheets, and databases; successful completion of the background investigation process.

Preferred Experience

Previous customer service skills and experience working in an office environment within a diverse community.

Preferred Education
Salary Range$7.25 – $8.00 per hour
Job Open Date04/06/2018
Job Close Date04/13/2018
Position StatusPart-Time
Special Instructions for Applicants
Quicklink for Postinghttp://employment.georgiasouthern.edu/postings/45580

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